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Announcement
		PancreasWeb 20/01/09 The Pancreatic Cancer Research Fund, a registered UK charity, is offering a Project Grant up to Ł150,000 for research into pancreatic cancer. Applications are invited for this award, which will be for 1-3 years and can cover salary or research costs, or a combination of the two (but no overheads). Basic and translational research is of particular interest and proposals will be judged on the basis of scientific excellence and innovation. The principal applicant should be based in a UK research group or institution, although proposals involving collaboration with a researcher or researchers outside the UK will be considered. Application form and further details are available from the charity. Email maggieblanks@pcrf.org.uk Closing date for applications is 29th May 2009. Further information about the charity can be found on its website http://www.pcrf.org.uk or by phoning Maggie Blanks on +44 (0) 208 360 1119.
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		PancreasWeb 21/01/09 This program (initiated in 2003) allows pancreatologists to become a member of the North American Pancreatic Study Group (NAPSG), the International Association of Pancreatology (IAP) and the European Pancreatic Club (EPC) for the very attractive flat fee of USD 200.00. In addition, triple members receive an online subscription to the journal Pancreatology and can profit from reduced registration fees for IAP and EPC meetings. Application form

New Content
		Alcohol use and cigarette smoking as risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis Debenedet, A.T., Raghunathan, T.E., Wing, J.J., Wamsteker, E.J., Dimagno, M.J. Clinical Gastroenterology and Hepatology 2009;7:353-358 PancreasWeb 29/04/09 Acute pancreatitis is the most common complication of ERCP, with a reported frequency of post-ERCP pancreatitis (PEP) ranging from 5 to 32% (1). PEP is defined as onset of new abdominal pain usually within 2h of completion of the procedure, persisting for a duration of at least 24h, and associated with a 3-fold elevation in serum amylase and/or lipase 24h after the procedure. In the majority of patients, PEP is mild, requiring only conservative treatment. The risk of PEP is determined …

News
		PancreasWeb 31.03.2009 According to researchers from the M.D. Anderson Cancer Center in Houston, TX, obesity greatly increases the risk for metastasis, recurrence and death in pancreatic cancer patients. The study, conducted by Jason B. Fleming, MD, and his team, included 285 patients who underwent potentially curative surgery for pancreatic adenocarcinoma. Overall median time
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		PancreasWeb 30.01.2009 According to researchers from the MD Anderson Cancer Center, University of Texas, variations in mismatch repair genes can help predict treatment response and prognosis in patients with pancreatic cancer. ‘There has been no biomarker for pancreatic cancer used in the clinic to predict response. Our research interest has been to determine whether genetic variation in DNA repair …
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		PancreasWeb 22/08/08 Following up on the hypothesis that pancreatic neoplasia may be initiated in progenitor-like cells, researchers from the Johns Hopkins University School of Medicine in Baltimore, Md., have created a zebrafish model of pancreatic cancer.
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		PancreasWeb 18/06/08 Results of a new study suggest that patients suffering from pancreatic cancer may benefit from a new treatment strategy involving gemcitabine. Richard Schilsky, MD, from the University of Chicago recently presented the results of a trial on the effects of gemcitabine administered after pancreatic cancer surgery. The researchers found that treatment with gemcitabine, compared to placebo, resulted in improvements in both disease-free and overall survival: …
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		PancreasWeb 28/04/08 Resveratrol, a natural antioxidant found in grape skins and wine, is believed to have anti-cancer, anti-inflammatory and anti-atherogenic effects, and to modulate cell growth. Researchers from the University of Rochester Medical Center (New York) have now shown that this agent can also help destroy pancreatic cancer cells by impairing mitochondria function. …
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		PancreasWeb 24/04/08 This book, Vol. 12 of the series 'Endocrine Development', presents in vivo and in vitro techniques to investigate pancreas development and islet cell function, as well as some reviews dealing with genetics. Special emphasis is placed on the investigation, management and treatment of neonatal diabetes. For further information about this title, visit its homepage
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		PancreasWeb 03/03/08 Until now, the existence of pancreatic stem cells in adult organisms has been questioned due to the lack of evidence to support this hypothesis. Previous studies suggested that the replication of adult β cells may be responsible for new β cells, rather than stem cells. Harry Heimberg, MD, and his team from the Juvenile Diabetes Research Foundation Center at Vrije Universiteit Brussel, Belgium, have now succeeded in isolating pancreatic β cell progenitors in adult mice: …
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		PancreasWeb 01/02/08 Researchers at the University Medical Center Utrecht, The Netherlands, found that treating patients suffering from severe acute pancreatitis with probiotics resulted in increased mortality. This was completely unexpected as previous smaller studies, …
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		PancreasWeb 28/01/08 The Latin American Pancreatic Study Group (LAPSG) is currently gathering information about the different existing criteria of diagnosis and treatment of chronic Pancreatitis. For this purpose, the study group has designed a survey to help determine those aspects that are problematic and will eventually allow a record of patients suffering from the disease in Latin American countries.¨ The study group is also organizing a workshop on 'Chronic Pancreatitis in Latin America' during the Congress of Gastroenterology and Digestive Endoscopy, to be held in Buenos Aires in August 2008. Interested parties are kindly invited to take part in the survey: Go to survey Executive Comitee LAPSG: Eduardo Cunha, Guillermo Robles Díaz, Claudio Gonzalez, Lidia Fabiano and María Vaccaro Scientific Secretary of the Congress of Gastroenterology and Digestive Endoscopy 2008: Silvia C. Gutierrez Chairman of the Congress of Gastroenterology and Digestive Endoscopy 2008: Dr. Luis Soifer
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		PancreasWeb 10/01/08 According to a study conducted by Ayelet Eppel, MD, and his colleagues at the Mt. Sinai Hospital, Toronto, a history of allergies or hay fever may protect from pancreatic cancer. Previous epidemiological studies - although somewhat inconsistent - support this finding. The researchers conducted a population-based case-control study in Ontario, recruiting incident cases of pancreatic adenocarcinoma
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		PancreasWeb 14/12/07 As of December 2007, the Ukrainian Pancreatic Club has joined the triple membership program initiated in 2003. This program allows pancreatologists to become a member of the respective National Society, the European Pancreatic Club (EPC) and the International Association …
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		PancreasWeb 10/12/07 According to a pooled analysis of data from previous clinical trials, Dr. Volker Heinemann (Klinikum Grosshadern, Munich, Germany) and his international team found that combining a platinum-based drug with gemcitabine may help extend the lives of some patients suffering from pancreatic cancer. Their rationale for exploring these combinations was the fact that preclinical studies indicate that gemcitabine …
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		PancreasWeb 09/11/07 According to a trial conducted by researchers of the Manchester Royal Infirmary, intravenous antioxidant therapy is ineffective, and may even be harmful, in cases of severe acute pancreatitis. Dr. Ajith K. Siriwardena and his colleagues recruited 43 well-matched patients to this randomized, placebo-controlled trial; Inclusion criteria were enrolment within 72 hours of onset of predicted severe …
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		PancreasWeb 18/10/69 Mistletoe extract has been used in Germany and Switzerland for a long time as supportive treatment in cancer patients, mainly to reduce adverse drug reactions and to improve quality of life. Dr. Harald Matthes (Berlin, Germany) and his coauthors have completed a study that evaluated the efficacy and safety of mistletoe extract in supportive care of surgically treated patients with pancreatic carcinoma (all stages), comparing them with a control group that did not receive the extract.
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		PancreasWeb 18/09/07 A major obstacle in the development of diagnostic biomarkers of early pancreatic cancer has been the dual expression of potential candidates in both chronic pancreatitis and pancreatic cancer. Ru Chen and her colleagues from the University of Washington, Seattle, systematically studied protein expression in chronic pancreatitis, using ICAT technology …
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		PancreasWeb 30/08/07 With the help of two novel complementary optical techniques, researchers from Northwestern University, Evanston, Ill., have been able to distinguish cancerous pancreatic tissue from normal tissue in a study published in the journal Clinical Cancer Research.
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		PancreasWeb 15/08/07 A molecularly engineered therapy selectively embeds a gene in pancreatic cancer that shrinks or eradicates tumors, inhibits metastasis and prolongs survival with virtually no toxicity, researchers from the University of Texas M.D. Anderson Cancer Center report in Cancer Cell.
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		PancreasWeb 30/07/07 The ground-breaking NOTES™ approach through the mouth provides a revolutionary and less invasive way to perform traditional surgical procedures A team of Baystate Medical Center physicians led by Dr. John Romanelli have performed the world’s first reported stapled NOTES™ cyst-gastrostomy on a chronically infected pancreatic pseudocyst. The surgeons decided on this procedure because prior endoscopic placement of stents had not yielded the desired results, …
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		PancreasWeb 13/07/07 The RON receptor tyrosine kinase has been found to be overexpressed and/or active in several cancers, but its role in pancreatic cancer has hitherto been unknown. Andrew Lowy, MD, and Susan Waltz, PhD, from the University of Cincinnati, are now reporting a possible link between this receptor and pancreatic cancer.
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		PancreasWeb 09/07/07 This new peer-reviewed online-only journal publishes original case reports covering the entire spectrum of gastroenterology. Clinicians and researchers are given a tool to disseminate their personal experience to a wider public as well as to review interesting cases encountered by colleagues all over the world. A search function across the entire growing collection of case reports facilitates the retrieval of specific information. Following the open access principle, the entire contents can be retrieved at no charge, guaranteeing easy access to this valuable source of anecdotal information at all times. Journal website
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		PancreasWeb 06/07/07 Surgeons at the University of Illinois Medical Center, Chicago, Ill., performed the first-ever robotic pancreatectomy in a 39-year-old male suffering from chronic familial pancreatitis. For this groundbreaking operation, the surgeons used the da Vinci surgical system, inserting the laparoscope and robotic arms …
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		PancreasWeb 25/04/07 Cromolyn, an anti-allergic drug that has been known for 40 years, has been found to significantly reduce tumor growth in animal models of human pancreatic cancer, also increasing the effectiveness of standard chemotherapy. Drawing on previous research, Craig Logsdon, PhD, and his team from the MD Anderson Cancer Center investigated the ability of cromolyn to block S100P function in a mouse model. …
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		Maria I. Vaccaro, Buenos Aires, Argentina PancreasWeb 18/04/07 Read report
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		Pancreas - Pathological Practice and Research PancreasWeb 13/04/07 Edited by K. Suda, Tokyo, this publication describes in detail various pathological changes in the behavior of the pancreas. Pathologists, physicians and surgeons who are interested in the pancreas will find it a useful reference source both for their daily work as well as for future research. Further information is available on the publication's homepage
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		PancreasWeb 19/03/07 There has been increasing evidence that the capability of a tumor to grow and propagate is in fact dependent on a small subset of cells within a tumor. Researchers from the University of Michigan Comprehensive Cancer Center have now discovered what may very well be pancreatic cancer stem cells. Diane Simeone, MD, and her fellow researchers have used a xenograft model, …
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		PancreasWeb 14/02/07 This novel method is based on an idea of John Kanzius, now retired former owner of Jet Broadcasting Co. When he was diagnosed with B-cell leukemia in 2002 and witnessed the impact of radiation and chemotherapy on fellow patients, Mr. Kanzius started to think about a new way to fight cancer, falling back on what he knows best – radio waves. His idea was to turn the cancer cells into …
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		PancreasWeb 01/02/07 Capsicain may play a major role in the development of the next generation of anti-cancer drugs, researchers from the Universities of Nottingham and Cardiff, UK, claim in a recently published study. Dr. Timothy Bates and his colleagues found that compounds belonging to the family of vanilloids, such as capsicain, can kill cancer cells …
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		PancreasWeb 19/01/07 Researchers at the University of Texas Southwestern Medical Center (Dallas) have discovered a noninvasive method to monitor and quantify vascular effects of antitumor therapy, using microbubbles targeted to tumor endothelium, and contrast ultrasound. Rolf A. Brekken, MD, and his team searched for a way to assess …

Commentary
		Alcohol use and cigarette smoking as risk factors for post-endoscopic retrograde cholangiopancreatography pancreatitis Debenedet, A.T., Raghunathan, T.E., Wing, J.J., Wamsteker, E.J., Dimagno, M.J. Clinical Gastroenterology and Hepatology 2009;7:353-358 PancreasWeb 29/04/09 Acute pancreatitis is the most common complication of ERCP, with a reported frequency of post-ERCP pancreatitis (PEP) ranging from 5 to 32% (1). PEP is defined as onset of new abdominal pain usually within 2h of completion of the procedure, persisting for a duration of at least 24h, and associated with a 3-fold elevation in serum amylase and/or lipase 24h after the procedure. In the majority of patients, PEP is mild, requiring only conservative treatment. The risk of PEP is determined …
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		Overexpression of Interleukin-1β in the Murine Pancreas Results in Chronic Pancreatitis Frederic Marrache et al. Gastroenterology 2008;135:1277-1287 PancreasWeb 08/11/08
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		Aggressive pancreatic resection for primary pancreatic neuroendocrine tumor: is it justifiable? Swee H. Teh, Clifford Deveney, Brett C. Sheppard Am J Surg 2007;193:610-613 PancreasWeb 14/05/07
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		Potential of adipocytokines in predicting peripancreatic necrosis and severity in acute pancreatitis: Pilot study Andreas Schäffler, Karin Landfried, Markus Völk, Alois Fürst, Christa Büchler, Jürgen Schölmerich, Hans Herfath J Gastroenterol Hepatol 2007;22:326-334 PancreasWeb 26/04/07
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		Early Endoscopic Intervention Versus Early Conservative Management in Patients with Acute Gallstone Pancreatitis and Biliopancreatic Obstruction. A Randomized Clinical Trial Oria A., Cimmino D., Ocamp C., Silva W., Kohan G., Zandalazini H., Szelagowski C., Chiappetta L. Ann Surg 2007;245:10-17 PancreasWeb 29/03/07
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		Does secretin-stimulated MRCP predict exocrine pancreatic insufficiency ? A comparison with non-invasive exocrine pancreatic function tests Arne RJ Schneider et al. J Clin Gastroenterol 2006;40:851-855 PancreasWeb 12/12/06
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		A prospective, randomized, placebo-controlled trial of transdermal glyceryl trinitrate in ERCP: effects on technical success and post-ERCP pancreatitis A.J. Kaffes, M.J. Bourke, S. Ding, A. Alrubaie, V. Kwan, S.J. Williams Gastrointest Endosc 2006;64:351-357 PancreasWeb 14/11/06
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		Implications and Cost of Pancreatic Leak Following Distal Pancreatic Resection J. Ruben Rodriguez, Santos Soto Germes, Pari V. Pandharipande, G. Scott Gazelle, Sarah P. Thayer, Andrew L. Warshaw, Carlos Fernandez-del Castillo Arch Surg 2006;141:361-366 PancreasWeb 28/06/06
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		Frozen sectioning of the pancreatic cut surface during resection of intraductal papillary mucinous neoplasms of the pancreas is useful and reliable. A prospective evaluation Couvelard, A., et al. Ann Surg 2005;242:774-780 PancreasWeb 26/01/06
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		A Proinflammatory, Antiapoptotic Phenotype Underlies the Susceptibility to Acute Pancreatitis in Cystic Fibrosis Transmembrane Regulator (-/-) Mice M.J. DiMagno et al Gastroenterology 2005;129:665-681 PancreasWeb 03/10/05
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		Treatment strategy of intraductal papillary-mucinous tumor of the pancreas Kenji Yamao J Gastroenterol 2005;40:773-774 PancreasWeb 20/09/05
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		Pathophysiology of Acute Experimental Pancreatitis: Lessons from Genetically Engineered Animal Models and New Molecular Approaches Schäfer, C., Tietz, A.B., Göke, B. Digestion 2005;71:162-172 PancreasWeb 12/07/05
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		MUC1 expression in primary and metastatic pancreatic cancer cells for in vitro treatment by 213Bi-C595 radioimmunoconjugate C.F. Qu et al. Br J Cancer 2004;91:2086-2093 PancreasWeb 02/06/05
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		Laboratory Markers of Severe Acute Pancreatitis B. Rau, M.K. Schilling, H.G. Beger Dig Dis 2004;22:247-257 PancreasWeb 14/03/05
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		Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment W.-N.P. Lee, P. Guo, S. Lim, S. Bassilian, S.T. Lee, J. Boren, M. Cascante, V.L.W. Go, L.G. Boros Br J Cancer, 2004;91:2094-2100 PancreasWeb 25/02/05

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